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THE PHARMA REVIEW (SEPTEMBER OCTOBER 2020)

Preclinical Screening and Animal Models of Human Disease: A Decisive Step for Clinical Study

Ms. Swarnima Negi1 & Dr. Sachdev Yadav2

Introduction: Preclinical screening and animal models are classical pharmacological models used as a mandatory element in preclinical (toxicological and pharmacological) studies of new drugs. The approaches using experimental animals are characterized by relatively high relevance and the data from the animal models are extrapolated to humans. A number of pharmacological models have proven relevance, such as streptozocin-induced diabetes in mice, digoxin-induced arrhythmias, experimental autoimmune encephalomyelitis - a model of multiple sclerosis, asthma, collagen-induced arthritis, and epilepsy induced by chemical agents or electric shock. In recent years, the replacement of animal testing and animal models with in-vitro models has been increasingly introduced into practice, but some studies still remain compulsory according to the modern manuals of pharmaco-toxicological preclinical study.

 

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