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THE PHARMA REVIEW (SEPTEMBER OCTOBER 2017)

Enhancement of Solubility and Dissolution Rate of Gliclazide by Solid Dispersion Technique

G.N.A. Lakshmi*, R. Raghu Nadhan & A. Lakshmana Rao

Introduction: Gliclazide is an oral hypoglycemic agent used in the treatment of type-II diabetes mellitus. It is a BCS class-II drug exhibiting low solubility. Being a poor soluble drug, an attempt was made to initially increase the solubility of the drug by solid dispersion technique using PEG-6000 and PEG-4000 polymers.

 
The aim of the present study is to develop and optimize immediate release tablets of Gliclazide of strength 80mg comparable to the innovators product. Solid dispersion showing good solubility was used in tablet preparation. Nine formulations of tablets are prepared by direct compression method using different disintegrating agents (Sodiun starch glycolate, Crospovidone and Croscaramelose sodium). The tablet blend was evaluated for various micromeritic properties and dissolution was carried out in 900ml of 0.1N HCl. Solid dispersion containing 1:3 ratio of drug and PEG-6000 has shown good solubility and formulation F9 with 15mg of sodium starch glycolate was found to give quick onset of action by rapidly disintegrating in a few minutes with better patient compliance. 

 

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