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THE PHARMA REVIEW (SEPTEMBER – OCTOBER 2017)

Effect of Formulation Factors on Orodispersible Triptan Formulatons– Novel Approach in Treatment of Migraine

Yella Sirisha1*, Dr.T.E.Gopala Krishna Murthy2 & Dr. Avanapu Srinivasa Rao3

Introduction: The present research work is an attempt to detrmine the effect of various diluents and superdisintegrants and design an optimised formulation for Oral disintegrating tablets of Eletriptan. It is a triptan drug used for the treatment of migraine headaches. The drug excipient compatibility study was done and no interactions were found, DSC & XRD studies were carried out. The tablets were formulated by direct compression method using Spray dried lactose, Mannitol, Microcrystalline cellulose (MCC), Starch as diluents and Crospovidone, Crosscarmellose sodium, Sodium starch glycolate as superdisintegrants. The pre-compression parameters like bulk density, tapped density, Carr’s Index, hausners ratio and angle of repose were determined and all the formulations were found to be within IP limits. The post compression parameters like the hardness, thickness, friability, weight variation, and disintegrating time in oral cavity for all the formulations were carried out and results were found to be as per IP limits. In-vitro drug release kinetics studies were carried out for all the formulations, of those the formulation F29 containing Crosscarmellose sodium (5%) & Mannitol as diluent, has shown better release and follows first order kinetics. The tablets were stored at 40±2˚C/75 ± 5% RH for three months to assess their stability of optimized formulation. 

 

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