HOME     CONTACT     BACK

 
 
 
THE PHARMA REVIEW APRIL - MAY 2007

Limulus Amebocyte Test Need For Harmonization

Kamla Pathak, Sunita Dahiya

Abstract: Pyrogens are fever producing materials that most often originate from gram negative bacterial cell wall but can also originate as leachates from some chemicals and materials. The literature classifies pyrogens into two broad classes namely the exogenous and endogenous pyrogens which can be further subclassified1, as depicted in Scheme 1. Exogenous pyrogens are foreign substances derived outside of host and produce febrile reaction, when administered parenterally to the host by stimulating the production and release of endogenous pyrogens from the host's phagocytic cell. Endogenous pyrogens could be produced by blood monocytes, eosinophils, alveolar macrophages and fixed tissue macrophages. Additionally, some chemical pyrogens may also produce fever by altering the body chemistry. However, the microbial exogenous pyrogens are more problematic for the pharmaceutical manufacturers rather than the nonmicrobial ones.

 
Go to Content Index Page

PHARMA REVIEW - ARTICLES ARCHIVE ( COMPLETE LIST)

The above content is an abstract only. For the full Article please contact:
KONGPOSH Publications Pvt. Ltd.
ICS House, C-19, Commercial Complex, SDA, Opp. IIT Gate, New Delhi, India -110016
Tel.: 26855839, 20057149, Fax: 91-11-26855876
Email: info@kppub.com / fpc@vsnl.com, Website: http://www.kppub.com

 
 
 

 Copyright 2008. KONGPOSH PUBLICATIONS Pvt. Ltd.