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THE PHARMA REVIEW APRIL - MAY 2007

Formulation and Invitro Evaluation of Aceclofenac - CD Tablets

K. P. R. Chowdary and A. Sambasiva Rao

Abstract: Aceclofenac - bCD and aceclofenac - HPbCD tablets were prepared by direct compression method employing Prosolve (50%) as directly compressible vehicle and were evaluated. In respect of drug content, hardness, friability, D.T. & dissolution. Aceclofenac - bCD tablets exhibited significantly higher dissolution rate and efficiency than plain and market aceclofenac tablets as well as aceclofenac - HPbCD tablets. A 12.7 fold increase in the dissolution rate of aceclofenac was observed with aceclofenac - bCD (1:2 ) tablets.

 
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