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THE PHARMA REVIEW (NOVEMBER DECEMBER 2019)

Formulation Development of Curcumin-β-CD Microspheres

Nisarg C Patel1 Anita P Patel2 & Jayvadan K Patel2

Introduction: The objective of this study was to design microspheres by the interpenetrating network (IPN) between Chitosan (CS) and Guargum (GG) as novel delivery systems for Curcumin-β-Cyclodextrin complex using w/o emulsion cross linking technique to enhance the bioavailability. Curcumin is a natural polyphenolic compound which shows preventive and therapeutic actions against cancer. Curcumin was complexed with β-Cyclodextrin to improve the pharmacokinetic and pharmacodynamic properties. This complex was prepared by freeze drying technique. Microspheres were prepared by w/o emulsion crosslinking method and glutaraldehyde (GA) was used as a crosslinking agent. Prepared microspheres were evaluated for Surface morphology, particle size, % drug entrapment, % yield, drug release profile and stability studies. The microspheres were nearly spherical. The particle size, percentage drug entrapment, percentage yield and % drug release were found 123.49 0.14 to 209.03 0.48 m, 71.13 0.03 to 85.2 0.07 %, 79.58 0.42 to 87.54 0.89 % and 76.61 0.27 to 91.85 1.38 % respectively. The optimized formulation for a period of 3 months at 402 C/755 % RH showed no significant changes. We concluded that the current approach was helpful to develop polysaccharide based microspheres of Curcumin to enhance colonic drug delivery.

 

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