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THE PHARMA REVIEW (MAY JUNE 2020)

Designing of Formulation of Sustain Release Tablet of Tacrolimus with Cotrimaxazole

Amit Swarnkar

Introduction: The first successful kidney transplant was performed by Dr. Joseph Murray, a plastic surgeon, in 1952. Since that time, significant advances in transplant surgery and immunologic research led to longer lives for solid organ transplant recipients (SOTRs). Resultant improved quality of life led to increased demand for plastic and reconstructive surgery in SOTRs. One common indication for surgical management in SOTRs is squamous cell carcinoma, which presents more frequently and at more advanced stage in SOTRs. In 2012, over 28,000 organ transplants were performed in the United States. Long-term survival of solid organ transplant recipients (SOTRs) has increased dramatically due to advancements in surgical technology and immunosuppressive therapies. Bacteria are the leading cause of infections after solid organ transplantation. In recent years, a progressive growth in the incidence of multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains has been observed. While methicillin-resistant Staphylococcus aureus(MRSA) infection is declining in non-transplant and SOT patients worldwide, vancomycin-resistant enterococci, MDR/XDR Enterobacteriaceae and MDR/XDR non-fermenters are progressively growing as a cause of infection in solid organ transplant (SOT) patients and represent a global threat. As the antibiotics active against MDR bacteria have several limitations for their use, which include less clinical experience, higher incidence of adverse effects and less knowledge of the pharmacokinetics of the drug, and, in most cases, are only available for parenteral administration. Manufacturing of tablet and syrup are usual in pharmaceutical field, all most all times patient need to take many tablet for different reason at a time or at a gap of certain period. It is difficult in case of pediatric patient to give many tablets as they generally refuse to take such therapy1.

 

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