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THE PHARMA REVIEW (MAY – JUNE 2019)

Nanocoutered Lipid-based Drug Delivery Strategies for Crossing Blood - Brain Barrier in Neurodegenerative Disorders

Sumant Saini1, Teenu Sharma1, Ranjot Kaur1, Atul Jain2 & Bhupinder Singh1,2*

Introduction: Present-day society is afflicted with a number of diseases, marked with different etiologies. Out of these umpteen health conditions, neurological disorders, especially neurodegenerative disorders, have sprung up as a major healthcare concern for various medical professionals worldwide. Neurodegeneration is verily an umbrella term used for the conditions in which the vitality and functionality of the nerve or the nervous systems is affected in a partial or complete manner. Afflicting damage to the cells of the nervous system, it comprises a number of disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). The neurons depart from their normal physiology, anatomy, and, in some cases, both. Neurodegeneration, as understood from the various scientific endeavors around the world, is a cocktail of multiple etiologies. In most cases, the exact cause of the symptoms is unknown, and the disease progresses in an unpredictable fashion. This significantly changes the biochemical homeostasis of the body, whereas the levels of biochemicals are either increased or decreased, causing dysregulation of the functionality of the neurons, leading consequently to their apoptosis or loss of their functionality and vitality. Such deleterious damage can span over a group of neurons, to a neuronal tissue, or to the entire nervous systems, depending on the severity of damage. Often, with the etiology of neurodegeneration being unknown and its progression being unpredictable, there is a progressive fall in the vitality and efficacy of the nervous system.

  

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