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THE PHARMA REVIEW (MAY – JUNE 2018)

The Quest for the Perfect D-value

Garrett Krushefski

Introduction:

Here’s a quick quiz!
Which of the following two steam biological indicators would be more difficult to kill?
Lot A has 2.0 X 105 spores per indicator, D121-value = 2.2-minutes,
Lot B has 3.3 X 106 spores per indicator, D121-value = 1.8-minutes.
Lot A has a slightly greater D-value but Lot B has more than ten times as many spores. So, which is more difficult to kill? Not sure? Keep reading and we’ll figure it out.
There are two aspects that together determine the overall resistance capabilities of a biological indicator: population and D-value. This edition of Spore News will evaluate these two aspects as well as discuss how specific one really needs to be when ordering a new lot of indicators.
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