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THE PHARMA REVIEW (MAY JUNE 2018)

Gastroretentive Drug Delivery System (GRDDS): A Novel Approach to Improve Therapeutic Efficacy

Dr. R. S. Thakur

Introduction: Controlled release (CR) dosage forms have been extensively used to improve therapeutic outcomes of several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to retain and localize the delivery system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability leads to unpredictable bioavailability and time to achieve peak plasma level. This article focus on various gastroretentive approaches that are leading methodologies in the field of site-specific orally administered controlled release drug delivery system. In order to understand various physiological difficulties to achieve gastric retention, important types of gastric retention systems have been summarized. Various gastroretentive approaches, designed and developed i.e. high density (sinking), floating, bio or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems are also explained. Finally, advantages of gastroretentive drug delivery systems are covered in detail.

 

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