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THE PHARMA REVIEW (MAY JUNE 2018)

Establishment of Linearity and Molar Absorptivity for Sulphanilamide, Sulphamethoxazole and Sulphadimidine by Direct UV Spectroscopy Method

K. Anusha, T. Mamatha, B. Dinesh, Dr. Anil Kumar# & Dr. Bayya Subba Rao*

Introduction: Sulpha drugs are well established anti-bacterial agents. Indian pharmacopoeial methods are a direct method of nitrite titration either using external indicator or potentiometric method. Reported methods include with coupling of diazotized sulpha drugs with certain reagents and later subjecting especially to visible spectroscopy. An attempt is made with respect to direct UV spectroscopy of individual selected sulpha drugs and is found promising for Sulphanilamide, Sulphamethoxazole and Sulphadimidine.

 

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