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THE PHARMA REVIEW (MARCH - APRIL 2018)

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Losartan By Using Natural Polymers

K N S Karthik*, K Ravi Kumar1 & P Bharghava Bhushan Rao2

Introduction: Losartan, a drug widely used in the treatment of hypertension. However, its extensive first pass metabolism results in poor bioavailability. The objective of present research work is to design and evaluate the sustained release mucoadhesive buccal tablets of Losartan with a goal to increase the bioavailability, reduce dosing frequency and improve patient compliance. The tablets were prepared using Gum Kondagagu, Gum Olibanum and Guar Gum as mucoadhesive polymers. Nine formulations were developed with varying concentration of polymers. The tablets were evaluated for hardness, weight variation, thickness, percentage of drug content, pH, in-vitro studies like swelling, mucoadhesive strength and drug release. Formulation (F6) containing Gum Olibanum with highest concentration showed good mucoadhesive strength (24.43) and maximum drug release of 99.15% in 6 hrs. Swelling increases with increase in concentration of Gum Olibanum in tablets. Swelling pH was found to be 6.10. Formulation (F6) followed zero-order drug release. The results indicate that the mucoadhesive buccal tablets of Losartan may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Losartan through buccal mucosa.

 

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