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THE PHARMA REVIEW OCTOBER 2006

A Novel Application of Hydrotropic Solubilization in the Spectrophotometric Estimation of Frusemide in Tablets

R.K. Maheshwari

Abstract: Several methods are used to increase the aqueous solubilities of poorly water-soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation, hydrotropic solution of sodium benzoate (2.0 M) has been employed as solubilizing agent to solubilize poorly water-soluble drug, frusemide, from fine powder of its tablets for spectrophotometric determination in ultraviolet region. Frusemide shows maximum absorbance at 330 nm. Beer's law was obeyed in the concentration range of 20 to 120 g/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is new, accurate, simple, cost-effective, environmentally friendly and can be successfully employed in routine analysis of frusemide tablets. Sodium benzoate did not interfere in estimation.

 
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